News Behind the Neuroscience News » Michael A. Collingwood http://neuromics.net Backstories that matter Wed, 04 Jan 2012 20:09:47 +0000 http://wordpress.org/?v=2.8.4 en hourly 1 Improving 27mer DsiRNA Preformance http://neuromics.net/weblog/post/28/ http://neuromics.net/weblog/post/28/#comments Mon, 21 Jul 2008 02:43:14 +0000 Pete Shuster http://neuromics.net/?p=28 The DsiRNA story marches forward with yet another important publication. We will give you an opportunity to upload the fulltext article at the end of this posting.

Dr. Mark Behlke, Dr John Rossi and team have been gaining deeper understanding of the Mechanism of Dicer-substrate small-interfering RNA (DsiRNA) processing. This understanding is leading to better and better designs of the RNA duplexes. These designs or chemical modifications are necessary steps in the drug design and development process.

This publication looks at design from the perspective of:

  • Nuclease Stability
  • Pharmacokinectics
  • immune response

I believe this is an important publication for researchers wanting to better understand:

  1.  The mechanisms behind successful delivery of DsiRNA for gene expression studies.
  2. Variations in potency.

upload article:  oligo-18-p187-2008-collingwood-dsirna-modifications1

 

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