Many of my backstories have featured Pain Researchers. In several, I have featured use of our our i-Fect ™ Transfection Kit for enhancing the delivery of siRNA in vitro and in vivo to study the expression of genes invovled in Neuropathic and Nociceptive Pain.
I am excited to present a recent publication that includes use of this kit [...]
I have featured successes with delivering siRNA in vivo in this blog. These included stories on Dr. Philipe Serrat and his team at the University of Sherbrooke and Dr. Mark Behlke’s work at Integrated DNA and Dicerna.
I am pleased to report the parade of success with use our i-FectTM in vivo grows.
Here’s the most recent study:
Christian Ndong, [...]
Researchers using siRNA complexed with our i-Fect ™ transfection regent have successfully knocked down ASIC3 Receptors in vivo. This publication joins the growing parade (starting with Luo et al, 2005) that reference successful modulation of receptors involved in pain using siRNA complexes. These studies all share animal behavior studies showing a marked change in response to pain [...]
Shedding Light on New Pain Pathways
There is no joy in Painville. Our answer to pain is: “make it go away”! It spoils quality of life. The socio-economic costs for treatments, loss of productivity and absenteeism, are measured in billions USD$.
Today, moderate to severe pain is treated mostly with NSAIDs, narcotics or tricyclics (anti-depressants). Properly prescribed, [...]
