DsiRNA was delivered in mice via IT injection using i-Fect. This added further support to the idea that the very potent DsiRNA coupled with a cationic delivery system that works in neurons is a very effective way to study the role of various genes in CNS function.
By Pete Shuster
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Posted in DsiRNA, Synaptic Transmissiom, featured researchers, i-Fect Transfection Kits
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Also tagged 27mer DsiRNA, Add new tag, Delivering DsiRNA, Deliverying siRNA in vivo, Dr. Jeffrey Mogil, Dr. Mark Behlke, Dr. Philippe Sarret, Gene Silencing Methods, intrathecal delivery of siRNA
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October 19, 2008 – 2:06 pm
Researchers using siRNA complexed with our i-Fect ™ transfection regent have successfully knocked down ASIC3 Receptors in vivo. This publication joins the growing parade (starting with Luo et al, 2005) that reference successful modulation of receptors involved in pain using siRNA complexes. These studies all share animal behavior studies showing a marked change in response to pain [...]
Dr. Mark Behlke and 27mer DsiRNAs
I am pleased to be featuring Dr. Mark Behlke’s story as our first. This was an easy choice because our main characters, Mark and the 27mer DsiRNAs (Dicer Substrate Small Interfering RNAs), are rising stars in small interfering (siRNA) based research.
siRNAtechnology addresses the need for Biosciences Researchers and Clinicians [...]
By Pete Shuster
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Posted in DsiRNA, People, Stories, featured researchers
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Also tagged 21mer siRNA, 27mer DsiRNA, Dicer Complex, Dicerna Pharmaceuticals, Dr. Dongho Kim, Dr. John Rossi, Dr. Mark Behlke, Dr. Philippe Sarret, Gene Silencing, Integrated DNA Technologies, NTS2 Gene, Pain Modulation, RISC, University of Sherbrooke
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