DsiRNA was delivered in mice via IT injection using i-Fect. This added further support to the idea that the very potent DsiRNA coupled with a cationic delivery system that works in neurons is a very effective way to study the role of various genes in CNS function.
By Pete Shuster
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Posted in DsiRNA, Synaptic Transmissiom, featured researchers, i-Fect Transfection Kits
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Also tagged Add new tag, Delivering DsiRNA, Deliverying siRNA in vivo, Dr. Jeffrey Mogil, Dr. Mark Behlke, Dr. Philippe Sarret, Gene Expression, Gene Silencing Methods, intrathecal delivery of siRNA
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October 1, 2008 – 7:52 pm
Just wanted to update you on my friends at Dicerna…from in vivo blog…
Wednesday, October 31, 2007
Dicerna Crashes RNAi Party
Life often imitates art, as the saying goes.
In “This Is Spinal Tap,” the classic rock and roll mockumentary chronicling the eponymous band, guitarist Nigel Tufnel famously brags that his amplifiers, unlike conventional ones that max out at [...]
Dr. Mark Behlke and 27mer DsiRNAs
I am pleased to be featuring Dr. Mark Behlke’s story as our first. This was an easy choice because our main characters, Mark and the 27mer DsiRNAs (Dicer Substrate Small Interfering RNAs), are rising stars in small interfering (siRNA) based research.
siRNAtechnology addresses the need for Biosciences Researchers and Clinicians [...]
By Pete Shuster
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Posted in DsiRNA, People, Stories, featured researchers
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Also tagged 21mer siRNA, Dicer Complex, Dicerna Pharmaceuticals, Dr. Dongho Kim, Dr. John Rossi, Dr. Mark Behlke, Dr. Philippe Sarret, Gene Expression, Gene Silencing, Integrated DNA Technologies, NTS2 Gene, Pain Modulation, RISC, University of Sherbrooke
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Learn the News Behind the News on 27mer DsiRNA. Includes the story of the how the potentcy of 27mer siRNA was discovered and exiting developments regarding the understanding of the role of the Dicer Complex and RISC. Also featured will be advances in 27mer oligo design and how the technology is being used in basic research and [...]
