DsiRNA was delivered in mice via IT injection using i-Fect. This added further support to the idea that the very potent DsiRNA coupled with a cationic delivery system that works in neurons is a very effective way to study the role of various genes in CNS function.
By Pete Shuster
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Also posted in DsiRNA, Synaptic Transmissiom, featured researchers
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Tagged 27mer DsiRNA, Add new tag, Delivering DsiRNA, Deliverying siRNA in vivo, Dr. Jeffrey Mogil, Dr. Mark Behlke, Dr. Philippe Sarret, Gene Expression, Gene Silencing Methods, intrathecal delivery of siRNA
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April 20, 2009 – 10:54 am
I have featured successes with delivering siRNA in vivo in this blog. These included stories on Dr. Philipe Serrat and his team at the University of Sherbrooke and Dr. Mark Behlke’s work at Integrated DNA and Dicerna.
I am pleased to report the parade of success with use our i-FectTM in vivo grows.
Here’s the most recent study:
Christian Ndong, [...]
By Pete Shuster
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Also posted in Pain Research, siRNA
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Tagged Add new tag, Dr. Jennifer Laird, Gene Silencing, i-Fect, in vivo RNAi, Inflammatory Pain, intrathecal delivery of siRNA, IT Delivery of siRNA, rat sensory neuron-specific receptor, snsr1, TRPV1
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