The Dance Between Immune System and Stem Cell Health

We named it the  immunoLinkTM 
We have been testing a growing number of Clients with our Quantibody Arrays. Many of of these clients have Autoimmune Disorder Diseases. These range from Rheumatoid Arthritis to Multiple Sclerosis.

These arrays are designed to precisely measure factors or markers(proteins) that are dysregulated by these diseases. We measure the levels of these biomarkers in our Clients’ Blood serum. The arrays have also been used to measure the levels of markers in plasma and cell culture supernatants.

Based on results, we are finding links between immune system and stem cell health. We call this the immunoLink. The link shows that when immune/inflammatory response markers are elevated, markers related to stem cell health are depleted.

Here we see the immune/inflammatory response markers IL-6, MCP-1 and TNF-alpha are elevated in our Clients with autoimmunity (A) vs Healthy Controls (HC). We also see lower levels of G-CSF and GM-CSF in these Clients.

G-CSF and GM-CSF are know to play a role in increasing circulating stem cells. GM-CSF is also know to be secreted by Mesenchymal Stem Cells (hMSCs) AND GM-CSF has anti-apoptotic functions on neurons, and is neuroprotective in animal stroke models while G-CSF has a prominent effect on the differentiation of adult neural stem cells (see: BMC Neuroscience 2007, doi:10.1186/1471-2202-8-88).

To us, the immunoLink means achieving a balance between immune system and stem cell health.

We provide immune system balancing and stem cell activating therapies for our Autoimmune Disease Clients and Children with Autism. We first do baseline and follow on testing (each 6 months) to determine how well the therapies are working. You can now benefit from one of our first Stem Cell Activating Product named Stem-Kine.

Dr. Joe Smarda, an applied immunologist, is user and promoter of Stem-Kine and oh, by the way. He is a European Porsche Cup Champion and pilots our Stem-Kine/Neuromics sponsored race car.

Our goal is to bring the many markers we test to healthier levels. As stem cell transplants become more common, moderating levels of immune/inflammatory response in patients could improve outcomes. If you would like to learn more, you can contact me at pshuster@neuromics.com or 612-801-1007.

Stem Cell Activators

Vitro Biopharma Receives Research Award for Innovative Research!

Vitro Biopharma Receives Frost & Sullivan Technology Innovation Leadership Award: 2014 Best Practices for Stem Cell Tools & Technology in North America

Golden, CO / ACCESSWIRE / July 9, 2014 / Vitro Diagnostics, Inc. (VODG), dba Vitro Biopharma, is pleased to announce receipt of a prestigious award from Frost & Sullivan. The award is based on independent analysis of competing companies’ commitment to innovation, commercial success, application diversity and fulfillment of unmet needs. Vitro Biopharma out-ranked competing firms in all areas evaluated.

Cecilia Van Cauwenberghe, industry analyst for Life Science/Biotech with Frost & Sullivan, noted, “The activation of endogenous stem cells to differentiate into specific cell types appears as an alternative to mitigate the significant remaining regulatory obstacles to adult stem cell transplantation in the United States. Vitro Biopharma is aligning its scheduled stages of clinical trials to test mobilization of endogenous stem cells in the treatment of traumatic brain injury and autism spectrum disorders (ASD), in which pre-clinical research strongly suggests the activation of certain biochemical pathways to increase proliferation, migration, and differentiation performance. Vitro Biopharma’s approach does not require stem cell transplantation, while providing a non-controversial, cost- and time-effective alternative to the current methodologies of competitors.” The full Award Statement is posted on our website.

Dr. Jim Musick, Vitro Biopharma’s president and CEO, said, “We are honored to receive this award from Frost & Sullivan, a premier organization dedicated to corporate growth and development, as well as business expansion. While embryonic stem cell research presents numerous ethical problems and has long been the subject of considerable debate, adult stem cells provide the benefits of embryonic stem cells without the problematic issues. A hallmark of embryonic stem cells is pluripotency, a capacity to develop into any cell in the body. While once thought to be exclusive to embryonic stem cells, it is now clear that adult stem cells may be converted to the functional equivalent of embryonic stem cells through methods that manipulate gene expression. These relatively straight-forward methods were developed and validated in several labs, including Vitro Biopharma. We are now also gaining understanding of the cellular signaling processes that activate adult stem cells, including MSCs, neural and muscle stem cells that reside within our bodies. This opens the possibility to elicit stem cell therapy without transplantation. There are also potential enhancements in mental and physical performance and anti-biological aging effects that have been demonstrated in animals. We look forward to expanding the power of stem cell activation to advancing medical treatments.”

Pete Shuster, a director of Vitro Biopharma and the CEO and founder of Neuromics, said, “Endogenous stem cell activation catalyzes the body’s natural healing processes. Proving this has been an integral part of our internally funded research. The ability to activate specific stem cell expansion, migration and differentiation pathways holds great promise for sufferers of traumatic brain injury and autism.”

“We are also encouraged by initial results treating autoimmune disease with natural stem cell activators. As previously reported, this initiative has generated revenue growth for Vitro Biopharma. Participating in TBI- and Autism-related trials would significantly accelerate this growth.”

“I consider this award a validation of our strategy and anticipate more good news to come as we continue to execute and improve this strategy.”