Spinal Cord Injury and Substance-P

I have featured Dr. Matt Ramer  and his research on Spinal Cord Injury. The focus was sensory and autonomic neuron repair.

As an update, I would like to share a publication that references SCI and our Substance-P antibody. Here Dr. Paul Dolber et al. found Substance P detected immunohistochemically in the sacral parasympathetic nucleus was significantly higher in 12 SCI rats than in 12 spinally intact rats (P = 0.008), suggesting substance P as a plausible candidate for the primary afferent neurotransmitter. raises the possibility that substance P may be important in the afferent limb of the spinal micturition reflex that develops about a week after spinal cord transection. This could provide a clue to alleviating urinary disorders related to SCI.

Xiaoyang Zhang, Kristy L.Douglas, Huixia Jin, Bassem M. Eldaif, Rashid Nassar, Matthew O. Fraser, and Paul C. Dolber. Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury. Am J Physiol Regul Integr Comp Physiol 295: R2084-R2096, 2008. doi:10.1152/ajpregu.90653.2008.

…guinea pig anti- Substance-P¬†(cat. no. GP14103, Neuromics, Minneapolis, MN) used at 1:1,000…