Dr. Steve Stice to Present the Power of StemEZ Neural Cells

STEMEZ hN2 Primary Human Neurons

STEMEZ hN2 Primary Human Neurons

I have profiled Steve Stice’s research here. The focus has been the excellent research results he and his team at ArunA Biomedical have generated with STEMEZ(TM) hN2 Human Neurons and hNP1 Human Neural Progenitors.

The story continues. He will be presenting the latest at the 9th Annual World Pharmaceutical Congress in Philadelphia, June 14. Topics include: using these neural cell lines to study neurotoxicity in cell-based assays and disease modeling.  Recent work conducted in outside laboratories demonstrates that these lines are more sensitive to environmental toxicants than traditional cellular models.

Sample high throughput assay applications:

  • Cell morphology and neurite outgrowth
  • Cell signaling and transcription factor expression
  • Receptor and ion channel function
  • Cytotoxicity
  • Apoptosis, genotoxicity and DNA damage

These capabilities has been confirmed by our customers. I look for the use of the STEMEZ cell lines to continue to grow as researchers discover their value in Drug Discovery and Basic Neuroscience capabilities.

Isolating and Maintaining Embryonic Stem Cells

I have featured Steve Stice and his team at ArunA Biomedical and UGA. They are pioneers in developing Embryonic Stem Cell Based Cultures and Assays for Drug Discovery and Basic Research. Given the importance of their work, I am commited to keeping my finger on the pulse of their advances and discoveries.

Here they isolate, and maintain in culture, neural progenitors demonstrating properties of these neural epithelial cells from WA09 human embryonic stem cells (hESCs):

D.W. Machacek, S. K. Dhara, C. Sturkie, K. Hasneen, D. Carter, L. Murrah Hanson, P.R. MacLeish, M. Benveniste, S.L. Stice. DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELL DERIVED NEURAL PROGENITORS INTO FUNCTIONALLY RESPONSIVE POPULATIONS IN THE ABSENCE OF EXOGENOUS EGF.