Learn the News Behind the News on 27mer DsiRNA. Includes the story of the how the potentcy of 27mer siRNA was discovered and exiting developments regarding the understanding of the role of the Dicer Complex and RISC. Also featured will be advances in 27mer oligo design and how the technology is being used in basic research and drug discovery.
Here’s a publication highlighting the roots of the story:
Dong Ho Kim, Mark Behlke, Scott Rose, Mi-Sook Chang, Sangdun Choi & John Rossi. Synthetic dsRNA Substrates Enhance RNAi Potency and Efficacy Nature Biotechnology. Published online 26 December 2004;doi10.1038/nbt1051.